A selective inhibitor of Aurora B kinase (IC50 = 10 µM)

ZM 447439 – 5 mg

Brand:
Cayman
CAS:
331771-20-1
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

The Aurora kinases have important roles in regulating mitosis and cytokinesis, with Aurora B involved in centromere function as part of the Chromosomal Passenger Complex, with survivin, INCENP, and borealin.{18317} ZM 447439 is a selective inhibitor of Aurora B kinase (IC50 = 50 nM), less potently inhibiting Aurora C and A (IC50 = 250 and 1,000 nM, respectively).{18314} It has no effect on several other kinases, including Cdk1, Cdk2, Cdk4, Plk1, CHK1, KDR2, and FAK (IC50 > 10 µM).{18316} ZM 447439 has been used to study the role of Aurora B in molecular events associated with mitosis and cytokinesis.{18316,18315} Moreover, ZM 447439 selectively inhibits proliferating cells rather than non-dividing cells, suggesting its potential in cancer therapy.{18314}  

 

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Description

A selective inhibitor of Aurora B kinase (IC50 = 10 µM), less potently inhibiting Aurora C and A (IC50 = 250 and 1,000 nM, respectively); has been used to study the role of Aurora B in molecular events associated with mitosis and cytokinesis; selectively inhibits proliferating cells rather than non-dividing cells

Formal name: N-[4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]-benzamide

Synonyms: 

Molecular weight: 513.6

CAS: 331771-20-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Aurora||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Cycle

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