A potent

VEGFR2 Kinase Inhibitor I – 5 mg

Brand:
Cayman
CAS:
15966-93-5
Storage:
-20
UN-No:
Non-Hazardous - /

Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms A, C, and D. VEGFR2 kinase inhibitor I is a potent, cell-permeable inhibitor of mouse VEGFR2 kinase (IC50 = 70 nM).{28800} It has little or no effect against receptors for platelet-derived growth factor, epidermal growth factor, or insulin-like growth factor (IC50 > 100 µM).{28800}  

 

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Description

A potent, cell-permeable inhibitor of mouse VEGFR2 kinase (IC50 = 70 nM); has little or no effect against PDGFR, EGFR or IGF1R kinases (IC50 > 100 µM)

Formal name: 5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid, ethyl ester

Synonyms:  SU 5408

Molecular weight: 310.4

CAS: 15966-93-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|VEGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors

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