A bioactive compound that inhibits the growth of bacteria and mycobacteria (minimal inhibitory concentration = 0.05 μg/ml); suppresses TNF-α-stimulated IL-8 production in HUVECs (IC50 = 0.01 μg/ml)

Celastramycin A – 1 mg

Brand:
Cayman
CAS:
491600-94-3
Storage:
-20
UN-No:
Non-Hazardous - /

Celastramycin A is a bioactive compound isolated from endophytic bacteria living in plants of the Celastraceae family.{17765} This benzoyl pyrrole inhibits the growth of bacteria and mycobacteria, with a minimal inhibitory concentration as low as 0.05 μg/ml.{17765} Celastramycin A also suppresses the production of IL-8 in human umbilical vein endothelial cells as stimulated by TNF-α (IC50 = 0.01 μg/ml).{17766}  

 

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Description

A bioactive compound that inhibits the growth of bacteria and mycobacteria (minimal inhibitory concentration = 0.05 μg/ml); suppresses TNF-α-stimulated IL-8 production in HUVECs (IC50 = 0.01 μg/ml)

Formal name: (3-chloro-5-hexyl-2,6-dihydroxyphenyl)(4,5-dichloro-1H-pyrrol-3-yl)-methanone

Synonyms: 

Molecular weight: 390.7

CAS: 491600-94-3

Purity: ≥97%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Natural Products|Pyrroles||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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