A benzoquinone ansamycin antibiotic which binds Hsp90 and its paralog GRP94; indirectly affects diverse cellular processes

Geldanamycin – 5 mg

Brand:
Cayman
CAS:
30562-34-6
Storage:
-20
UN-No:
Non-Hazardous - /

Geldanamycin is a benzoquinone ansamycin antibiotic which binds heat shock protein 90 (Hsp90) and its paralog GRP94, altering their actions.{15573,18242,18246} Through its interaction with these chaperones, geldanamycin indirectly affects numerous client proteins with roles in diverse cellular processes, including gene expression, cell proliferation, apoptosis, and angiogenesis. For example, geldanamycin inhibits c-jun expression in human colon adenocarcinoma HT29 cells (IC50 = 75 nM), inhibiting AP-1 binding.{18245} It also reduces signaling through mitogenic signaling proteins and interferes with steroid receptor function.{15573,18247,18243,18244} Inhibitors of Hsp90, including geldanamycin, show promise in cancer therapy.{18248}  

 

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Description

A benzoquinone ansamycin antibiotic which binds Hsp90 and its paralog GRP94; indirectly affects diverse cellular processes, including gene expression, cell proliferation, apoptosis, and angiogenesis; inhibits c-jun expression in HT29 cells (IC50 = 75 nM); shows promise in cancer therapy

Formal name: 13R-hydroxy-8S,14S,19-trimethoxy-4,10,12S,16R-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4E,6E,10E,18-pentaen-9S-yl, carbamate

Synonyms:  NSC 122750

Molecular weight: 560.6

CAS: 30562-34-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Heat Shock Proteins||Research Area|Cell Biology|Cellular Chaperones||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Neuroscience

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