A widely-used non-specific inhibitor of cAMP and cGMP PDEs (IC50 = 19

IBMX – 1 g

Brand:
Cayman
CAS:
28822-58-4
Storage:
-20
UN-No:
Non-Hazardous - /

IBMX is a widely-used non-specific inhibitor of cyclic AMP and cyclic GMP phosphodiesterases (PDEs) (IC50 = 19, 50, 18, 13, 32, 7, and 50 μM for PDE1, PDE2, PDE3, PDE4, PDE5, PDE7, and PDE11, respectively). PDE8A, PDE8B, and PDE9 are insensitive to IBMX.{17520} By inhibiting PDEs, IBMX increases cellular cAMP and cGMP levels, activating cyclic-nucleotide-regulated protein kinases. Methylxanthines, including IBMX, caffeine, and theophylline, bind adenosine receptors, typically antagonizing the suppressive effects of natural agonists.{17521}  

 

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Description

A widely-used non-specific inhibitor of cAMP and cGMP PDEs (IC50 = 19, 50, 18, 13, 32, 7, and 50 μM for PDE1, PDE2, PDE3, PDE4, PDE5, PDE7, and PDE11, respectively)

Formal name: 3,9-dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione

Synonyms:  1-Methyl-3-Isobutylxanthine|Isobutylmethylxanthine|NSC 165960|SC-2964

Molecular weight: 222.3

CAS: 28822-58-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Cell Biology|Cell Signaling|cAMP Signaling||Research Area|Cell Biology|Cell Signaling|cGMP Signaling

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