A tyrosine kinase inhibitor best known as an inhibitor of VEGFR2 (FLK1/KDR) and a suppressor of tumor vascularization

SU 5416 – 10 mg

Brand:
Cayman
CAS:
204005-46-9
Storage:
-20
UN-No:
Non-Hazardous - /

SU 5416 is a tyrosine kinase inhibitor best known as an inhibitor of the vascular endothelial growth factor receptor (VEGFR2; FLK1/KDR) and a suppressor of tumor vascularization, preventing the growth of multiple tumor types. In addition to inhibiting VEGFR2 (IC50 = 1 μM), SU 5416 also inhibits PDGFR (IC50 = 20 μM), c-Kit (IC50 = 30 nM), RET (IC50 = 170 nM), FLT3 (IC50 = 160 nM), ABL (IC50 = 11 μM), and ALK (IC50 = 1.2 μM).{17237,17238,17239} SU 5416 does not inhibit epidermal growth factor or fibroblast growth factor receptor tyrosine kinases (IC50 > 100 μM).{17237}  

 

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Description

A tyrosine kinase inhibitor best known as an inhibitor of VEGFR2 (FLK1/KDR) and a suppressor of tumor vascularization, preventing the growth of multiple tumor types

Formal name: 3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one

Synonyms:  NSC 696819|Semaxinib|Sugen 5416|VEGFR 2 Kinase Inhibitor

Molecular weight: 238.3

CAS: 204005-46-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Kinase Inhibitors|VEGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors

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