An inhibitor of adenylyl cyclase (IC50 = 13 μM) that inhibits PGE1-stimulated increases in cAMP levels in intact platelets; used to evaluate adenylyl cyclase activity during iloprost-induced vasorelaxation

SQ 22,536 – 25 mg

Brand:
Cayman
CAS:
17318-31-9
Storage:
-20
UN-No:
Non-Hazardous - /

SQ 22,536 is an inhibitor of adenylyl cyclase with an IC50 value of 13 μM for inhibition of prostaglandin E1-stimulated increase in cAMP in intact platelets.{20863} It has been used to evaluate adenylyl cyclase activity during iloprost-induced vasorelaxation of isolated pulmonary veins or aorta in several research paradigms, inhibiting cAMP elevation at concentrations of 100-300 μM without effecting relaxation.{20861,20862}  

 

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Description

An inhibitor of adenylyl cyclase (IC50 = 13 μM) that inhibits PGE1-stimulated increases in cAMP levels in intact platelets; used to evaluate adenylyl cyclase activity during iloprost-induced vasorelaxation, inhibiting cAMP elevation (100-300 μM) without effecting relaxation

Formal name: 9-(tetrahydro-2-furanyl)-9H-purin-6-amine

Synonyms:  NSC 53339

Molecular weight: 205.2

CAS: 17318-31-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cell Biology|Cell Signaling|cAMP Signaling

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