An inactive stereoisomer (IC50 ≥ 1 mM) of the Cdk5 inhibitor olomoucine; may have utility as a control compound for determining Cdk5 specificity; rapidly inhibits dopamine transporter activity in rat dorsal striatal synaptosomes with an IC50 value of ~37 μM

Iso-Olomoucine – 50 mg

Brand:
Cayman
CAS:
101622-50-8
Storage:
-20
UN-No:
Non-Hazardous - /

Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression whose function/dysfunction has been implicated in cancer, a subset of human neurodegenerative diseases, and the reward response of addictive drugs via alteration of postsynaptic dopamine receptor signaling. Iso-olomoucine is an inactive stereoisomer of the Cdk5 inhibitor olomoucine. Because iso-olomoucine lacks activity at Cdk5 (IC50 ≥ 1 mM){15005}, it may have utility as a control compound for determining Cdk5 specificity.{19825,19826,19824} In a Cdk5-independent manner, iso-olomoucine has been shown to rapidly inhibit dopamine transporter activity in rat dorsal striatal synaptosomes with a potency similar to that of olomoucine (IC50 ~37 μM).{19825}  

 

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Description

An inactive stereoisomer (IC50 ≥ 1 mM) of the Cdk5 inhibitor olomoucine; may have utility as a control compound for determining Cdk5 specificity; rapidly inhibits dopamine transporter activity in rat dorsal striatal synaptosomes with an IC50 value of ~37 μM

Formal name: 2-[[7-methyl-6-[(phenylmethyl)amino]-7H-purin-2-yl]amino]-ethanol

Synonyms: 

Molecular weight: 298.3

CAS: 101622-50-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CDKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Cycle

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