A selective inhibitor of matrix metalloproteinase-2 (MMP-2) demonstrating an IC50 value of 12 nM; significantly less potent towards MMP-1

ARP 100 – 5 mg

Brand:
Cayman
CAS:
704888-90-4
Storage:
-20
UN-No:
Non-Hazardous - /

Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins to enable cell migration.{16569} During cancer progression both MMP-2 and MMP-9 play a role in metastatic tumor dispersion and angiogenesis. ARP 100 is a biphenylsulfonamide that acts as a selective inhibitor of MMP-2 demonstrating an IC50 value of 12 nM.{17394,17393} Due to its specific zinc binding domain configuration, the inhibitory activity of ARP 100 is significantly less potent towards MMP-1, MMP-3, MMP-7, and MMP-9 (IC50 values are 50, 4.5, 50, and 2 µM, respectively).{17394,17393} At 50 nM, ARP 100 suppresses the invasive behavior of HT1080 tumor cells grown on matrigel.{17394}  

 

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Description

A selective inhibitor of matrix metalloproteinase-2 (MMP-2) demonstrating an IC50 value of 12 nM; significantly less potent towards MMP-1, MMP-3, MMP-7, and MMP-9 (IC50 = 50, 4.5, 50, and 2 µM, respectively); suppresses invasive behavior of HT1080 tumor cells grown on matrigel at 50 nM

Formal name: 2-[([1,1′-biphenyl]-4-ylsulfonyl)(1-methylethoxy)amino]-N-hydroxy-acetamide

Synonyms:  ​Matrix Metalloproteinase-2 Inhibitor III|CAY10609|MMP-2 Inhibitor III

Molecular weight: 364.4

CAS: 704888-90-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases

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