A potent inhibitor of GSK3β (IC50 = 22 nM)

Indirubin-3′-monoxime – 1 mg

Brand:
Cayman
CAS:
160807-49-8
Storage:
-20
UN-No:
Non-Hazardous - /

Indirubin-3’-oxime is a potent inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = 22 nM).{14994} As GSK3β phosphorylates tau protein, indirubin-3’-oxime prevents tau phosphorylation both in vitro and in vivo at Alzheimer’s disease-relevant sites.{14994} It also inhibits cyclin-dependent kinases (CDKs) at higher concentrations, including Cdk1/cyclin B (IC50 = 180 nM), Cdk2/cyclin A (IC50 ~500 nM), Cdk2/cyclin E (IC50 = 250nM), Cdk4/cyclin D1 (IC50 = 3.3 µM) and Cdk5/p35 (IC50 = 100 nM). Indirubin-3’-oxime reversibly inhibits the proliferation of many cells types, arresting cycling in the G2/M phase.{17246,17247}  

 

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Description

A potent inhibitor of GSK3β (IC50 = 22 nM), preventing tau phosphorylation both in vitro and in vivo

Formal name: 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one

Synonyms: 

Molecular weight: 277.3

CAS: 160807-49-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CDKs||Product Type|Biochemicals|Kinase Inhibitors|GSK3||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Cycle||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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