Inhibits several isoforms of protein kinase C (PKC; IC50 = 7

Gö 6983 – 5 mg

Brand:
Cayman
CAS:
133053-19-7
Storage:
-20
UN-No:
Non-Hazardous - /

Gö 6983 inhibits several isoforms of protein kinase C (PKC; IC50 = 7, 7, 6, 10, 60, and 20,000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ, and PKCμ, respectively).{9055} It provides cardioprotective effects in myocardial ischemia/reperfusion by attenuating contractile dysfunction.{17421,17420}  

 

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Description

Inhibits several isoforms of protein kinase C (PKC; IC50 = 7, 7, 6, 10, 60, and 20,000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ, and PKCμ, respectively); provides cardioprotective effects in myocardial ischemia/reperfusion

Formal name: 3-[1-[3-(dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

Synonyms: 

Molecular weight: 442.5

CAS: 133053-19-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cardiovascular System|Heart|Myocardial Contractility||Research Area|Cell Biology|Cell Signaling

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