A competitive inhibitor of PC-PLC (Ki = 6.4 µM); has no effect on bacterial phosphatidylinositol-specific PLC

D609 (potassium salt) – 10 mg

Brand:
Cayman
CAS:
83373-60-8
Storage:
-20
UN-No:
Non-Hazardous - /

D609 is a xanthate and a competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC; Ki = 6.4 µM).{26211} It has no effect on bacterial phosphatidylinositol-specific PLC, bovine pancreatic PLA2, or phospholipase D.{26213} D609 reduces sphingomyelin synthase activity by 55.5 and 90.5% in membrane preparations when used at concentrations of 100 and 200 mg/ml, respectively.{26214} Similar to other xanthates, D609 has antioxidant, antiviral, and anti-tumor activities.{26213} In addition, it has anti-inflammatory actions, inhibiting LPS-stimulated expression of nitric oxide synthase (NOS) in phagocytes (IC50 = 20 µg/ml) and IL-1β-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in endothelial cells.{26212,3364}  

 

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Description

A competitive inhibitor of PC-PLC (Ki = 6.4 µM); has no effect on bacterial phosphatidylinositol-specific PLC, bovine pancreatic PLA2, or phospholipase D; reduces sphingomyelin synthase activity by 55.5 and 90.5% in membrane preparations when used at concentrations of 100 and 200 mg/ml, respectively; has antioxidant, antiviral, and anti-tumor activities; inhibits LPS-stimulated NOS expression in phagocytes (IC50 = 20 µg/ml) and IL-1β-induced VCAM-1 expression in endothelial cells

Formal name: O-(octahydro-4,7-methano-1H-inden-5-yl) ester, carbonodithioic acid, monopotassium salt

Synonyms:  Tricyclodecan-9-yl xanthogenate

Molecular weight: 266.5

CAS: 83373-60-8

Purity: ≥90%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|Phospholipases||Product Type|Biochemicals|Small Molecule Inhibitors|Sphingolipid Turnover||Research Area|Cancer||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Viral Diseases||Research Area|Lipid Biochemistry|Glycerophospholipids|Phospholipases||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity

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