A weak inhibitor of PKC demonstrating an IC50 value >100 µM; blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 value of 8 µM

Bisindolylmaleimide V – 10 mg

Brand:
Cayman
CAS:
113963-68-1
Storage:
-20
UN-No:
Non-Hazardous - /

Bisindolylmaleimide V (BIM V) is a weak inhibitor of protein kinase C (PKC) demonstrating an IC50 value >100 µM.{17278,17275,17276} While effectively inactive as a PKC inhibitor, BIM V blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 value of 8 µM.{17279}  

 

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Description

A weak inhibitor of PKC demonstrating an IC50 value >100 µM; blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 value of 8 µM

Formal name: 3,4-di-1H-indol-3-yl-1-methyl-1H-pyrrole-2,5-dione

Synonyms:  BIM V|Ro 31-6045

Molecular weight: 341.3

CAS: 113963-68-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|S6K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling

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