A tyrphostin that is a poor inhibitor of EGFRK (IC50 = 450 μM) and PDGFRK (IC50 > 100 μM) which has been found to inhibit the phosphorylation of ERK1 and ERK2 at 25-50 μM; blocks the production of TNF-α

AG-126 – 1 mg

Brand:
Cayman
CAS:
118409-62-4
Storage:
-20
UN-No:
Non-Hazardous - /

Tyrphostins are a family of protein tyrosine kinase inhibitors originally developed to inhibit cell growth by blocking the activity of certain growth factor receptor kinases (GFRK). The tyrphostin AG-126 selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM.{17267,17268} It blocks the production of TNF-α in vitro{17268} and in vivo,{17267} attenuating signaling through NF-κB,{17267} the induced expression of COX-2 and iNOS,{17269,17266} and the inflammatory response in diverse animal models.{17269,17270} AG-126 is a poor inhibitor of epidermal GFRK (IC50 = 450 μM){14963} and platelet-derived GFRK (IC50 > 100 μM).{14964}  

 

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Description

A tyrphostin that is a poor inhibitor of EGFRK (IC50 = 450 μM) and PDGFRK (IC50 > 100 μM) which has been found to inhibit the phosphorylation of ERK1 and ERK2 at 25-50 μM; blocks the production of TNF-α, attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response

Formal name: 2-[(3-hydroxy-4-nitrophenyl)methylene]-propanedinitrile

Synonyms:  Tyrphostin AG-126

Molecular weight: 215.2

CAS: 118409-62-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation

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