A partial agonist for the CB1 receptor and a neutral antagonist for the CB2 receptor with Ki values of 5.6 and 7.9 nM

CB-86 – 5 mg

Brand:
Cayman
CAS:
1150586-64-3
Storage:
-20
UN-No:
De Minimis - 1170 / 3

CB-86 is a resorcinol-anandamide hybrid compound that acts as a partial agonist for the central cannabinoid (CB1) receptor and a neutral antagonist for the peripheral cannabinoid (CB2) receptor with Ki values of 5.6 and 7.9 nM, respectively.{18014} Its demonstrated potency is similar to that of WIN 55,212-2 (Ki = 21 and 2.1 nM for CB1 and CB2, respectively).{18014} CB-86 (1 mg/kg) exhibits antinociceptive effects in mice treated with formalin.{18014}  

 

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Description

A partial agonist for the CB1 receptor and a neutral antagonist for the CB2 receptor with Ki values of 5.6 and 7.9 nM, respectively; at 1 mg/kg, exhibits antinociceptive effects in mice treated with formalin

Formal name: N-cyclopropyl-8-[3-(1,1-dimethylheptyl)-5-hydroxyphenoxy]-octanamide

Synonyms: 

Molecular weight: 417.6

CAS: 1150586-64-3

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Cannabinoid Research|CB1 & CB2 Receptors||Research Area|Neuroscience|Pain Research

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