A potent

PF-3845 – 10 mg

Brand:
Cayman
CAS:
1196109-52-0
Storage:
-20
UN-No:
Non-Hazardous - 2811 / 6.1

Fatty acid amide hydrolase (FAAH) degrades N-acyl ethanolamines (NAEs), including the endocannabinoid arachidonoyl ethanolamide (AEA). PF-3845 is a potent, selective, and irreversible inhibitor of FAAH (Ki = 0.23 μM).{17090} It covalently binds FAAH on Ser241 at the catalytic site, resulting in prolonged elevation of AEA in the brain and plasma in rats after treatment.{17090} PF-3845 significantly and persistently reduces inflammatory pain in rats through a cannabinoid receptor-dependent mechanism.{17090}  

 

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Description

A potent, selective, and irreversible inhibitor of FAAH (Ki = 0.23 μM); produces prolonged elevation of AEA in the brain and plasma in rats after treatment; significantly and persistently reduces inflammatory pain in rats through a CB receptor-dependent mechanism

Formal name: N-3-pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide

Synonyms: 

Molecular weight: 456.5

CAS: 1196109-52-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Fatty Acid Metabolism||Research Area|Neuroscience|Cannabinoid Research|CB1 & CB2 Receptors||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids||Research Area|Neuroscience|Pain Research

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