A form of 4-HNE with a terminal alkyne; for use in linking reactions (click chemistry) for detection of 4-HNE-modified DNA and proteins

4-hydroxy Nonenal Alkyne – 500 µg

Brand:
Cayman
CAS:
1011268-23-7
Storage:
-80
UN-No:
De Minimis - 1231 / 3

4-hydroxy Nonenal (4-HNE) is a major aldehyde produced during the lipid peroxidation of ω-6 polyunsaturated fatty acids, such as arachidonic acid and linoleic acid.{869,1103} It is considered a potential causal agent in numerous diseases, including chronic inflammation, neurodegenerative diseases, atherosclerosis, diabetes, and cancer, in part because it covalently modifies DNA and proteins resulting in genetic mutations and altered cell signaling, respectively.{18126} 4-HNE Alkyne is a form of 4-HNE with a terminal alkyne. Such terminal alkyne groups can be used in linking reactions, known as click chemistry, characterized by high dependability and specificity of azide-alkyne bioconjugation reactions.{17991,17992} Click chemistry has only recently been applied to the study of oxidized lipids.{16188}  

 

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Description

A form of 4-HNE with a terminal alkyne; for use in linking reactions (click chemistry) for detection of 4-HNE-modified DNA and proteins

Formal name: 4-hydroxynon-2E-nonen-8-ynal

Synonyms:  Click Tag™ 4-HNE Alkyne

Molecular weight: 152.2

CAS: 1011268-23-7

Purity: ≥98%

Formulation: A solution in methyl acetate

Application|Click Chemistry||Product Type|Biochemicals|Labeling & Detection|Reactive Probes||Product Type|Biochemicals|Lipids|Fatty Alcohols/Aldehydes||Research Area|Cancer||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Lipid Biochemistry|Fatty Acids||Research Area|Lipid Biochemistry|Reactive O2/N2 Pathways||Research Area|Neuroscience||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation

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