The dextrorotary isomer of L-DOPA; converted to L-DOPA via sequential oxidation and transamination

D-DOPA – 500 mg

Brand:
Cayman
CAS:
5796-17-8
Storage:
-20
UN-No:
Non-Hazardous - /

D-DOPA is an enantiomer of the dopamine precursor L-DOPA (Item No. 13248). It can be converted to L-DOPA via sequential oxidation and transamination, which are mediated by D-amino acid oxidase (DAAO) and DOPA transaminase, respectively, in rat kidney homogenates.{57222} It reduces the number of dopaminergic neurons in primary rat embryonic mesencephalic cultures in a concentration-dependent manner.{57223} Intraventricular administration of D-DOPA (200 µg/animal) increases striatal dopamine levels in rats.{57224} D-DOPA (20 mg/kg, i.p.) induces contralateral turns in a rat model of Parkinson’s disease induced by 6-OHDA (Item No. 25330).{57225}  

 

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Description

The dextrorotary isomer of L-DOPA; converted to L-DOPA via sequential oxidation and transamination, which are mediated by DAAO and DOPA transaminase, respectively, in rat kidney homogenates; reduces the number of dopaminergic neurons in primary rat embryonic mesencephalic cultures in a concentration-dependent manner; increases striatal dopamine levels in rats at 200 µg/animal; induces contralateral turns in a rat model of 6-OHDA-induced Parkinson’s disease at 20 mg/kg

Formal name: 3-hydroxy-D-tyrosine

Synonyms: 

Molecular weight: 197.2

CAS: 5796-17-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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