A potent inhibitor of calcium release-activated calcium channels in lymphocytes (IC50 = 100 nM); also inhibits lung IL-4 and CysLT generation in animal models of asthma

YM-58483 – 25 mg

Brand:
Cayman
CAS:
223499-30-7
Storage:
-20
UN-No:
Non-Hazardous - /

Calcium release-activated calcium (CRAC) channels mediate sustained calcium influx in electrically non-excitable cells. CRAC channels are activated by the release of calcium from intracellular stores, as induced by inositol trisphosphate. CRAC channel activation is essential for the activation of leukocytes and the production of cytokines and inflammatory mediators. YM-58483 is a potent inhibitor of CRAC channels, blocking thapsigargin-induced sustained calcium influx, Th2 cytokine production, and NF-AT-driven promoter activity in T lymphocytes (IC50 = 100 nM).{17153} YM-58483 also inhibits lung interleukin-4 and cysteinyl leukotriene generation as well as airway eosinophil infiltration in animal models of asthma.{16984}  

 

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Description

A potent inhibitor of calcium release-activated calcium channels in lymphocytes (IC50 = 100 nM); also inhibits lung IL-4 and CysLT generation in animal models of asthma

Formal name: N-[4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide

Synonyms:  BTP 2

Molecular weight: 421.3

CAS: 223499-30-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma

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