A competitive antagonist of S1P1 and S1P3 receptors (pKis = 7.86 and 5.93

VPC 23019 – 5 mg

Brand:
Cayman
CAS:
449173-19-7
Storage:
-20
UN-No:
Non-Hazardous - /

Sphingosine-1-phosphate (S1P; Item No. 62570) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.{11895,12477,10628} It exerts its activity by binding to five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8.{11895,12477} VPC 23019 is an aryl amide-containing S1P analog that acts as a competitive antagonist at both S1P1 and S1P3 receptors (pKis = 7.86 and 5.93, respectively).{12407} It can inhibit S1P-induced migration of thyroid cancer cells, ovarian cancer cells, and neural stem cells.{17724}  

 

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Description

A competitive antagonist of S1P1 and S1P3 receptors (pKis = 7.86 and 5.93, respectively); inhibits S1P-induced migration of thyroid cancer cells, ovarian cancer cells, and neural stem cells

Formal name: (R)-2-amino-3-((3-octylphenyl)amino)-3-oxopropyl dihydrogen phosphate

Synonyms: 

Molecular weight: 372.4

CAS: 449173-19-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cell Biology|Stem Cell Research||Research Area|Lipid Biochemistry|Sphingolipids

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