An inhibitor of SIRT1 and SIRT2

Salermide – 50 mg

Brand:
Cayman
CAS:
1105698-15-4
Storage:
-20
UN-No:
Non-Hazardous - /

The sirtuins (SIRTs) are a family of NAD+-dependent histone deacetylases involved in gene regulation that is relevant to, e.g., longevity, cancer, gene regulation, energy homeostasis, and apoptosis.{15106,16291} Salermide is an inhibitor of SIRT1 and SIRT2, causing tumor-specific apoptotic cell death.{16699} In MOLT4 leukemia cells, salermide causes 90% apoptosis within 72 hours (IC50 ~ 20 μM) by reactivating proapototic genes that are repressed by SIRT1.{16699}  

 

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Description

An inhibitor of SIRT1 and SIRT2, causing tumor-specific apopoptic cell death; causes 90% apoptosis within 72 hours (IC50 ~ 20 μM) by reactivating proapototic genes that are repressed by SIRT1 in MOLT4 leukemia cells

Formal name: N-[3-[[(2-hydroxy-1-naphthalenyl)methylene]amino]phenyl]-a-methyl-benzeneacetamide

Synonyms: 

Molecular weight: 394.5

CAS: 1105698-15-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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