An inhibitor of HDACs

M 344 – 50 mg

Brand:
Cayman
CAS:
251456-60-7
Storage:
-20
UN-No:
Non-Hazardous - /

M 344 is an inhibitor of histone deacetylases (HDACs), inhibiting maize HDAC (IC50 = 100 nM){17304} as well as human HDAC1 (IC50 = 46 nM).{17305} It shows a three-fold selectivity for inhibition of HDAC6 over HDAC1 (IC50s = 88 and 249 nM, respectively).{17306} M 344 enhances the sensitivity of human squamous carcinoma cells to radiation{17307} and promotes cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells (ED50 = 2.3 μM).{17308}  

 

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Description

An inhibitor of HDACs, inhibiting maize HDAC (IC50 = 100 nM) as well as human HDAC1 (IC50 = 46 nM); shows a 3-fold selectivity for HDAC6 over HDAC1 (IC50s = 88 and 249 nM, respectively)

Formal name: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide

Synonyms:  D237|Histone Deacetylase Inhibitor III|MS 344

Molecular weight: 307.4

CAS: 251456-60-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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