A potent and selective inhibitor of HDAC6 (IC50 = 0.002 nM

CAY10603 – 10 mg

Brand:
Cayman
CAS:
1045792-66-2
Storage:
-20
UN-No:
Non-Hazardous - /

Histone deacetylase 6 (HDAC6) is a class II HDAC that represses transcription by removing acetyl groups from histones. In addition, HDAC6 deacetylases tubulin, which is important in regulating microtubule stability and function. CAY10603 is a potent and selective inhibitor of HDAC6 (IC50 = 0.002 nM, as compared with 271, 252, 0.42, 6851, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively).{16594} Also, CAY10603 prevents the growth of several pancreatic cancer cell lines (IC50 = 0.1-1 μM).{16594} The HDAC6 inhibitor is more active in inhibiting cell growth than the broad spectrum HDAC inhibitor suberoylanilide hydroxamic acid (SAHA).  

 

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Description

A potent and selective inhibitor of HDAC6 (IC50 = 0.002 nM, as compared with 271, 252, 0.42, 6851, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively); prevents the growth of several pancreatic cancer cell lines (IC50 = 0.1-1 μM)

Formal name: N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-1,1-dimethylethyl ester, carbamic acid

Synonyms:  HDAC 6 inhibitor|Histone Deacetylase Inhibitor VIII

Molecular weight: 446.5

CAS: 1045792-66-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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