A cell-permeable

AGK2 – 25 mg

Brand:
Cayman
CAS:
304896-28-4
Storage:
-20
UN-No:
Non-Hazardous - /

Mammalian sirtuin 2 (SIRT2) is a nicotinamide adenine dinucleotide-dependent histone deacetylase (HDAC) with roles in cell cycle progression and tumorigenesis. AGK2 is a cell-permeable, selective inhibitor of SIRT2 (IC50 = 3.5 μM) that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.{17495} It rescues dopamine neurons from α-synuclein toxicity in both in vitro and in vivo Parkinson’s disease models, mimicking the effect of siRNA-mediated blockade of SIRT2 expression.{17495} AGK2 may be a useful tool for studying the roles of SIRT2 in neurodegeneration and aging, as well as cell cycle progression and tumorigenesis.  

 

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Description

A cell-permeable, selective inhibitor of SIRT2 (IC50 = 3.5 μM) that minimally affects either SIRT1 or SIRT3; rescues dopamine neurons from α-synuclein toxicity in both in vitro and in vivo Parkinson’s disease models

Formal name: 2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide

Synonyms: 

Molecular weight: 434.3

CAS: 304896-28-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Cell Biology|Cell Cycle||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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