A naturally-occurring anthraquinone with diverse effects

Emodin – 50 mg

Brand:
Cayman
CAS:
518-82-1
Storage:
-20
UN-No:
Non-Hazardous - /

Emodin is a naturally-occurring anthraquinone found in a variety of plants used in traditional Chinese medicine. Purified emodin has diverse effects, including the suppression of inflammation, dyslipidemia, and cancer.{21482,21479,21480} At a molecular level, emodin directly and selectively inhibits casein kinase II (IC50 = 0.89 μM).{21491,21488} Through this action, it inhibits the COP9 signalosome, causing the stabilization of the tumor suppressor p53.{21488} Moreover, emodin acts as a phytoestrogen, binding human estrogen receptors and blocking 17β-estradiol binding with Ki values of 0.77 and 1.5 μM for ERα and ERβ, respectively.{21490}  

 

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Description

A naturally-occurring anthraquinone with diverse effects, including the suppression of inflammation, dyslipidemia, and cancer; directly and selectively inhibits CK2 (IC50 = 0.89 μM) and the COP9 signalosome; acts as a phytoestrogen, blocking 17β-estradiol binding to ER with Ki values of 0.77 and 1.5 μM for ERα and ERβ, respectively

Formal name: 1,3,8-trihydroxy-6-methyl-9,10-anthracenedione

Synonyms:  Archin|Frangulic Acid|NSC 408120|NSC 622947|Schuttgelb

Molecular weight: 270.2

CAS: 518-82-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CK2||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Receptor Pharmacology||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Carbohydrate Kinase Signaling||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|p53||Research Area|Immunology & Inflammation

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