A small diffusible signaling molecule produced in Y. pseudituberculosis that is involved in quorum sensing

N-pentadecanoyl-L-Homoserine lactone – 50 mg

Brand:
Cayman
CAS:
182359-66-6
Storage:
-20
UN-No:
Non-Hazardous - /

Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.{15370} This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.{13434} Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which generally consists of a fatty acid coupled with homoserine lactone (HSL). Regulation of bacterial quorum sensing signaling systems to inhibit pathogenesis represents a new approach to antimicrobial therapy in the treatment of infectious diseases.{15369} AHLs vary in acyl group length (C4-C18), in the substitution of C3 (hydrogen, hydroxyl, or oxo group), and in the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signal specificity through the affinity of transcriptional regulators of the LuxR family.{15398} C15-HSL is a product of Y. pseudituberculosis.{15932}  

 

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Description

A small diffusible signaling molecule produced in Y. pseudituberculosis that is involved in quorum sensing, controlling gene expression, and affecting cellular metabolism

Formal name: N-[(3S)-tetrahydro-2-oxo-3-furanyl]-pentadecanamide

Synonyms:  C15-HSL

Molecular weight: 325.5

CAS: 182359-66-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Homoserine Lactones||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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