A small molecule activator of p53 that decreases the growth of BL2 Burkitt’s lymphoma and ARN8 melanoma cells; inhibits the deacetylase activity of purified human SIRT1 and SIRT2

Tenovin-1 – 100 mg

Brand:
Cayman
CAS:
380315-80-0
Storage:
-20
UN-No:
Non-Hazardous - /

Tenovin-1 is a small molecule activator of p53 transcriptional activity. At 10 µM, it elevates p53 expression in MCF-7 cells within two hours of treatment and longer-term exposure significantly decreases the growth of BL2 Burkitt’s lymphoma and ARN8 melanoma cells.{16243} Functioning upstream of p53, tenovin-1 acts by inhibiting the deacetylase activity of purified human SIRT1 and SIRT2, members of NAD+-dependent class III histone deacetylases that belong to the sirtuin family.{16243} While tenovin-1 demonstrates low genotoxicity, the compound has poor water solubility, which limits its uses in vivo.  

 

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Description

A small molecule activator of p53 that decreases the growth of BL2 Burkitt’s lymphoma and ARN8 melanoma cells; inhibits the deacetylase activity of purified human SIRT1 and SIRT2

Formal name: N-[[[4-(acetylamino)phenyl]amino]thioxomethyl-4-(1,1-dimethylethyl)]-benzamide

Synonyms: 

Molecular weight: 369.5

CAS: 380315-80-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Transcription Factors & Coactivators||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|p53||Research Area|Epigenetics, Transcription, & Translation|Erasers

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