A small molecule that induces autophagy and selectively causes lethality in renal cell carcinoma cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM)

STF-62247 – 25 mg

Brand:
Cayman
CAS:
315702-99-9
Storage:
-20
UN-No:
Non-Hazardous - /

STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM).{17445} It significantly reduces the growth rate of tumors formed from VHL-deficient cells in mice.{17445,17446,17447} STF-62247 induces cytotoxicity in VHL-positive RCC cells only at higher concentrations (IC50 = 16 μM).{17445}  

 

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Description

A small molecule that induces autophagy and selectively causes lethality in renal cell carcinoma cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM)

Formal name: N-(3-methylphenyl)-4-(4-pyridinyl)-2-thiazolamine

Synonyms: 

Molecular weight: 267.3

CAS: 315702-99-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Autophagy||Research Area|Cancer|Cell Death||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy

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