An active site-directed agent that inhibits serine proteinases with trypsin-like activity; may also act non-selectively with thiol groups and thereby inhibit cysteine proteinases and other enzymes

Tosyllysine Chloromethyl Ketone (hydrochloride) – 100 mg

Brand:
Cayman
CAS:
4272-74-6
Storage:
-20
UN-No:
De Minimis - 3335 / 9

Tosyllysine chloromethylketone (TLCK) is an active site-directed agent that inhibits serine proteinases with trypsin-like activity. TLCK may also act non-selectively with thiol groups and thereby inhibit cysteine proteinases and other enzymes.{13825} To prevent proteolytic degradation, TLCK may be used in protein purification protocols.{16785} TLCK selectively inactiviates clostripain obtained from C. histolyticum.{16786}  

 

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Description

An active site-directed agent that inhibits serine proteinases with trypsin-like activity; may also act non-selectively with thiol groups and thereby inhibit cysteine proteinases and other enzymes

Formal name: N-[5-amino-1-(2-chloroacetyl)pentyl]-4-methyl-benzenesulfonamide, monohydrochloride

Synonyms:  1-Chloro-3-Toxylamide-7-Amino-L-2-Heptanone|TLCK

Molecular weight: 369.3

CAS: 4272-74-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases

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