A potent

PD 173074 – 5 mg

Brand:
Cayman
CAS:
219580-11-7
Storage:
-20
UN-No:
Non-Hazardous - /

The fibroblast growth factor receptors (FGFRs) are cell surface receptors with intrinsic tyrosine kinase activity, which is necessary for receptor activation and signal propagation. PD 173074 is a potent and selective inhibitor of FGFR tyrosine kinase activity, blocking autophosphorylation of FGFR1 with an IC50 value of 21.5 nM.{17312} For comparison, it weakly inhibits PDGFR and c-Src (IC50 = 17.6 and 19.8 μM, respectively) and has no effect on EGFR, InsR, MEK, or PKC.{17312} PD 173074 also prevents signaling, at nanomolar levels, through FGFR2-5.{17313,17314,17315,17316,17317} Inhibition of FGFR signaling using PD 173074, impairs angiogenesis as well as self-renewal of stem cells via ERK1/2 activation.{17313,17316,17317,17318,17319}  

 

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SKU: 13032 - 5 mg Category:

Description

A potent, selective inhibitor of FGFR tyrosine kinase activity, blocking autophosphorylation of FGFR1 (IC50 = 21.5 nM); impairs angiogenesis, as well as self-renewal of stem cells via ERK1/2 activation

Formal name: N-[2-[[4-(diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N’-(1,1-dimethylethyl)-urea

Synonyms: 

Molecular weight: 523.7

CAS: 219580-11-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|FGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors||Research Area|Cell Biology|Stem Cell Research

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