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13,14-dihydro-15-keto Prostaglandin D2 – 5 mg

Brand:
Cayman
CAS:
59894-07-4
Storage:
-80
UN-No:
De Minimis - 1231 / 3

13,14-dihydro-15-keto Prostaglandin D2 (13,14-dihydro-15-keto PGD2) is a metabolite of PGD2 (Item No. 12010) which is formed through the 15-hydroxy PGDH pathway. 13,14-dihydro-15-keto PGD2 was recently identified as a selective agonist for the CRTH2/DP2 receptor.{5248} It also inhibits ion flux in a canine colonic mucosa preparation.{9769} In humans, 13,14-dihydro-15-keto PGD2 is further metabolized to give 11β-hydroxy compounds which have also undergone β-oxidation of one or both side chains. Virtually no 13,14-dihydro-15-keto PGD2 survives intact in the urine.{418,35}  

 

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SKU: 12610 - 5 mg Category:

Description

13,14-dihydro-15-keto PGD2 is a metabolite of PGD2 which is formed through the 15-hydroxy PGDH pathway. 13,14-dihydro-15-keto PGD2 was recently identified as a selective agonist for the CRTH2/DP2 receptor.{5248} It also inhibits ion flux in a canine colonic mucosa preparation.{9769} In humans, 13,14-dihydro-15-keto PGD2 is further metabolized to give 11β-hydroxy compounds which have also undergone β-oxidation of one or both side chains. Virtually no 13,14-dihydro-15-keto PGD2 survives intact in the urine.{418,35}

Formal name: 9α-hydroxy-11,15-dioxo-prost-5Z-en-1-oic acid

Synonyms:  13,14-dihydro-15-keto PGD2

Molecular weight: 352.5

CAS: 59894-07-4

Purity: ≥95%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Lipids|Prostaglandins||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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