Butyrolactone 3 – 5 mg

Brand:
Cayman
CAS:
778649-18-6
Storage:
-20
UN-No:
Non-Hazardous - /

Gcn5 is a chromatin modifying factor whose HAT activity is required to acetylate histone H3 lysine 9 (K9) and K14, which facilitates transcription elongation by relaxing nucleosomes. Butyrolactone 3 specifically inhibits the histone acetyltransferase Gcn5 with an IC50 value of 100 μM and has an affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3.{21590} Butyrolactone 3 can inhibit pre-RNA splicing with an IC50 value of 0.5 mM and as such has been used to investigate Gcn5/PCAF-like HAT functions during assembly of spliceosome before pre-mRNA translation.{21589}  

 

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SKU: 12095 - 5 mg Category:

Description

Specifically inhibits the histone acetyltransferase Gcn5 (IC50 = 100 μM) and can inhibit pre-RNA splicing with an IC50 value of 0.5 mM


Formal name: rel-tetrahydro-4-methylene-5-oxo-2R-propyl-3S-furancarboxylic acid

Synonyms: 

Molecular weight: 184.2

CAS: 778649-18-6

Purity: ≥95%

Formulation: A crystalline solid


Product Type|Biochemicals|Small Molecule Inhibitors|Acetyltransferases||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Acetylation