A stereoisomer of the antitumor anthracycline doxorubicin that undergoes β-glucuronidation

Epirubicin (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
56390-09-1
Storage:
-20
UN-No:
Non-Hazardous - /

Epirubicin is a stereoisomer of the antitumor anthracycline doxorubicin (Item No. 15007) that undergoes β-glucuronidation, which partially detoxifies the dose-limiting side effects that are present with doxorubicin.{22870} Compared to doxorubicin, epirubicin is equally cytotoxic to HeLa cells (ID50s = 9 μM).{22870} When used either alone or in combination therapies, epirubicin has been shown to demonstrate high rates of complete or partial remission in various cancers including advanced ovary, lymphomas, breast, pancreas, gastric, hepatocellular carcinoma, head and neck tumors, and colorectal.{22870,20978}  

 

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Description

A stereoisomer of the antitumor anthracycline doxorubicin that undergoes β-glucuronidation, which partially detoxifies the dose-limiting side effects that are present with doxorubicin; equally cytotoxic to HeLa cells compared to doxorubicin (ID50s = 9 μM)

Formal name: (8S,10S)-10-[(3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione, monohydrochloride

Synonyms:  4’-Epidoxorubicin

Molecular weight: 580

CAS: 56390-09-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Death

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