An immunosuppressant drug that binds cyclophilin D

Cyclosporin A – 100 mg

Brand:
Cayman
CAS:
59865-13-3
Storage:
-20
UN-No:
Non-Hazardous - /

Cyclosporin A is an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells (IC50 = 5 nM).{24989,20555,25125} It blocks the transcription of genes involved in T cell activation by interfering with the calcineurin-driven nuclear import of the transcription factor NFAT.{24989,21639,21213} Because of its powerful immunosuppressant activity, cyclosporin A has long been used for the prevention of transplant rejection.{25124}  

 

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SKU: 12088 - 100 mg Category:

Description

An immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells (IC50 = 5 nM), which interferes with the nuclear import of NFAT, a transcription factor involved in T cell activation; used for the prevention of transplant rejection

Formal name:

Synonyms:  NSC 290193

Molecular weight: 1,202.60

CAS: 59865-13-3

Purity: ≥99%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Immunosuppressants

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