A synthetic prodrug which is converted to the vitamin D receptor agonist 1

1-hydroxy Vitamin D3 – 10 mg

Brand:
Cayman
CAS:
41294-56-8
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer, and immunity.{15096,19429} 1-hydroxy Vitamin D3 is a synthetic prodrug which is converted by cytochrome P450 isoforms to the vitamin D receptor agonist 1,25-dihydroxy vitamin D3 in vivo.{21568,21563} Such prodrugs are effective in suppressing the synthesis and secretion of parathyroid hormone in secondary hyperparathyroidism, an action which requires the vitamin D receptor.{21564,21563,21567} 1-hydroxy Vitamin D3 supports bone growth both in postmenopausal women and in glucocorticoid-induced osteoporosis.{21585,21586} It also provides renal and cardiovascular protection during chronic kidney disease.{21565,21584}  

 

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SKU: 12082 - 10 mg Category:

Description

A synthetic prodrug which is converted to the vitamin D receptor agonist 1,25-dihydroxy vitamin D3 in vivo; suppresses the synthesis and secretion of parathyroid hormone in secondary hyperparathyroidism; supports bone growth; provides renal and cardiovascular protection during chronic kidney disease

Formal name: 5-[2E-[(3aS)-1R-[1R,5-dimethylhexyl]octahydro-7aR-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1R,3R-cyclohexanediol

Synonyms:  1-Hydroxycholecalciferol|Alfacalcidol|Bondiol|Etalpha|Oxydevit|Tevabone

Molecular weight: 400.6

CAS: 41294-56-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Vitamins||Research Area|Cardiovascular System|Kidney & Renal Disease|Chronic Kidney Disease||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Endocrinology & Metabolism|Cofactors & Vitamins||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Vitamin D Receptor

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