A pyridine regio-isomer of GSK-J1 which poorly inhibits JMJD3 (IC50 > 100 μM)

GSK-J2 (sodium salt) – 5 mg

Brand:
Cayman
CAS:
2108665-15-0
Storage:
-20
UN-No:
Non-Hazardous - /

The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer.{19496,19494} GSK-J2 is a pyridine regio-isomer of GSK-J1 which poorly inhibits JMJD3 (IC50 > 100 μM), making it an appropriate negative control for in vitro studies involving GSK-J1.{21388} For in vivo research, cell-permeable prodrug forms of GSK-J1 and GSK-J2 are available as GSK-J4 (Item No. 12073) and GSK-J5 (Item No. 12074), respectively. See the Structural Genomics Consortium (SGC) website for more information.  

 

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SKU: 12056 - 5 mg Category:

Description

A pyridine regio-isomer of GSK-J1 which poorly inhibits JMJD3 (IC50 > 100 μM), making it an appropriate negative control for in vitro studies involving GSK-J1

Formal name: 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-3-yl)pyrimidin-4-yl)amino)propanoic acid, monosodium salt

Synonyms: 

Molecular weight: 412.4

CAS: 2108665-15-0

Purity: ≥90%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Negative Controls||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Demethylation

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