An antagonist of histamine H3 receptors (Ki = 43.8 nM); selective for H3 over H1 and H2 receptors (IC50 = >10

GT 2016 – 1 mg

Brand:
Cayman
CAS:
152241-24-2
Storage:
-20
UN-No:
Non-Hazardous - /

GT 2016 is an antagonist of histamine H3 receptors (Ki = 43.8 nM).{51179} It is selective for H3 over H1 and H2 receptors (IC50 = >10,000 nM for both) and lacks activity against kidney and brain histamine methyltransferase at concentrations up to 3 μM. In vivo, GT 2016 (10 and 30 mg/kg) increases histamine release in the rat parietal cortex.  

 

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SKU: 11996 - 1 mg Category:

Description

An antagonist of histamine H3 receptors (Ki = 43.8 nM); selective for H3 over H1 and H2 receptors (IC50 = >10,000 nM for both) and lacks activity against kidney and brain histamine methyltransferase at in vivo at 10 and 30 mg/kg

Formal name: 5-​cyclohexyl-​1-​[4-​(1H-​imidazol-​5-​yl)​-​1-​piperidinyl]​-1-​pentanone

Synonyms: 

Molecular weight: 317.5

CAS: 152241-24-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience

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