A dopamine D2S

(S)-Pramipexole (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
104632-25-9
Storage:
-20
UN-No:
Non-Hazardous - /

(S)-Pramipexole is a dopamine D2S, D2L, D3, and D4 receptor agonist (EC50s = 426.58, 338.84, 2.24, and 128.82 nM, respectively, in a [35S]GTPγS binding assay).{21786} It is also a partial agonist of α2A-adrenergic receptors (α2A-ARs; EC50 = 3,548.13 nM). (S)-Pramipexole is selective for dopamine D2-4 receptors (Kis = 954.99, 1,698.24, 12.59, 128.82 nM for for D2S, D2L, D3, and D4 receptors, respectively, in a radioligand binding assay) over D1 and D5 receptors (Kis = >10,000 nM for both).{21785} It prevents MPTP-induced decreases in the number of dopaminergic neurons in the substantia nigra pars compacta in common marmosets when administered at a dose of 60 μg/kg per day before, during, and after administration of MPTP.{53929} Formulations containing (S)-pramipexole have been used in the treatment of Parkinson’s disease and restless legs syndrome.  

 

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Description

A dopamine D2S, D2L, D3, and D4 receptor agonist (EC50s = 426.58, 338.84, 2.24, and 128.82 nM, respectively, in a [35S]GTPγS binding assay); a partial agonist of α2A-ARs (EC50 = 3,548.13 nM); selective for dopamine D2-4 receptors (Kis = 954.99, 1,698.24, 12.59, 128.82 nM for for D2S, D2L, D3, and D4 receptors, respectively, in a radioligand binding assay) over D1 and D5 receptors (Kis = >10,000 nM for both); prevents MPTP-induced decreases in the number of dopaminergic neurons in the substantia nigra pars compacta in common marmosets at 60 μg/kg per day before, during, and after administration of MPTP

Formal name: (6S)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazolediamine, dihydrochloride

Synonyms:  (–)-Pramipexole

Molecular weight: 284.2

CAS: 104632-25-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease||Research Area|Neuroscience|Neuroprotection

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