An inhibitor of NADPH-oxidase complex assembly that at 300 μM is effective in preventing the production of superoxide in human white blood cells or neutrophilic granulocytes; widely used as an inhibitor of NADPH oxidase activity in the treatment of various inflammatory diseases

Apocynin – 5 g

Brand:
Cayman
CAS:
498-02-2
Storage:
-20
UN-No:
Non-Hazardous - /

Apocynin is a compound isolated from the traditional medicinal plant P. kurroa and structurally related to vanillin that acts as an inhibitor of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity.{22116} Upon oxidation by myeloperoxidase, apocynin inhibits the assembly of a functional NADPH-oxidase complex that is responsible for reactive oxygen species production.{22114,22115} At 300 μM it is effective in preventing the production of superoxide in human white blood cells or neutrophilic granulocytes, but does not however obstruct the phagocytic or other defense roles of granulocytes.{22116,22114,22115,22117} Due to the selectivity of its inhibition, apocynin can be widely used as an inhibitor of NADPH oxidase without interfering in other aspects of the immune system. It has been used in the treatment of arthritis, bowel disease, asthma, atherosclerosis, and familial amyotrophic lateral sclerosis.{22116}  

 

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SKU: 11976 - 5 g Category:

Description

An inhibitor of NADPH-oxidase complex assembly that at 300 μM is effective in preventing the production of superoxide in human white blood cells or neutrophilic granulocytes; widely used as an inhibitor of NADPH oxidase activity in the treatment of various inflammatory diseases

Formal name: 1-(4-hydroxy-3-methoxyphenyl)-ethanone

Synonyms:  Acetoguaiacone|Acetovanillone|NSC 209524|NSC 2146

Molecular weight: 166.2

CAS: 498-02-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Immunology & Inflammation|Arthritis (Non-autoimmune)||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Myeloperoxidase

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