A fungal metabolite with immune modulating activities; prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs; acts as an agonist at S1P receptors when phosphorylated; enhances activity of Abcb1 and Abcc1 and inhibits cytosolic PLA2 activity

Fingolimod – 50 mg

Brand:
Cayman
CAS:
162359-55-9
Storage:
-20
UN-No:
Non-Hazardous - /

Fingolimod is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb I. sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.{11265} Fingolimod is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5).{11284} Down-regulation of S1P1 receptors on T and B lymphocytes by fingolimod results in defective egress of these cells from spleen, lymph nodes, and Peyer’s patch.{11738} Fingolimod also enhances the activity of the sphingosine transporter Abcb1 and the leukotriene C4 transporter Abcc1 and inhibits cytosolic phospholipase A2 (PLA2) activity.{11283,14604}  

 

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SKU: 11975 - 50 mg Category:

Description

A fungal metabolite with immune modulating activities; prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs; acts as an agonist at S1P receptors when phosphorylated; enhances activity of Abcb1 and Abcc1 and inhibits cytosolic PLA2 activity

Formal name: 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol

Synonyms: 

Molecular weight: 307.5

CAS: 162359-55-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Small Molecule Inhibitors|Phospholipases||Research Area|Immunology & Inflammation|Adaptive Immunity

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