A selective CB1 receptor antagonist (Ki = 0.7 nM); reverses cannabinoid agonist-mediated responses

CP 945,598 (hydrochloride) – 25 mg

Brand:
Cayman
CAS:
686347-12-6
Storage:
-20
UN-No:
Non-Hazardous - /

CP 945,598 (hydrochloride) is a selective antagonist of the cannabinoid receptor CB1 with a Ki value of 0.7 nM and demonstrates relatively low affinity for CB2 receptors (Ki = 7.6 µM).{32999,33000} It is reported to reverse cannabinoid agonist-mediated responses (i.e., hypo-locomotion, hypothermia, analgesia, and catalepsy), to reduce food intake, and to increase energy expenditure as well as fat oxidation in rats.{32999,33000}  

 

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SKU: 11955 - 25 mg Category:

Description

A selective CB1 receptor antagonist (Ki = 0.7 nM); reverses cannabinoid agonist-mediated responses

Formal name: 1-[8-(2-chlorophenyl)-9-4-chlorophenyl)-9H-purine-6-yl]-4-ethylamino)-4-piperidinecarboxamide, monohydrochloride

Synonyms:  Otenabant

Molecular weight: 546.9

CAS: 686347-12-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Endocrinology & Metabolism||Research Area|Neuroscience|Cannabinoid Research|CB1 & CB2 Receptors

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