An α2-AR agonist (EC50 = 0.65 μM for contraction of canine sapheneous veins); induces concentration-dependent inhibition of the twitch response in rat vas deferens and guinea pig ileum; induces sedation and reduces motor activity in mice

B-HT 933 (hydrochloride) – 25 mg

Brand:
Cayman
CAS:
36067-72-8
Storage:
-20
UN-No:
Non-Hazardous - /

B-HT 933 is an agonist of α2-adrenergic receptors (α2-ARs) with an EC50 value of 0.65 μM for contraction of canine sapheneous veins.{35207} It induces concentration-dependent inhibition of the twitch response in rat vas deferens and guinea pig ileum.{35209} B-HT 933 induces sedation and reduces motor activity in mice, an effect that is reversed by the α2-AR antagonist yohimbine (Item No. 19869).{35211} B-HT 933 decreases blood pressure and cardiac output in cats injected with 30 μg/kg intracisternally.{32515} It also exhibits antinociceptive effects in mice with ED50 values of 12.5, 20.5, and 6.1 mg/kg for the tail-immersion, tail-pinch, and acetic acid writhing tests, respectively.{35216}  

 

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Description

An α2-AR agonist (EC50 = 0.65 μM for contraction of canine sapheneous veins); induces concentration-dependent inhibition of the twitch response in rat vas deferens and guinea pig ileum; induces sedation and reduces motor activity in mice, an effect that is reversed by the α2-AR antagonist yohimbine; decreases blood pressure and cardiac output in cats injected with 30 μg/kg intracisternally; exhibits antinociceptive effects in mice (ED50s = 12.5, 20.5, and 6.1 mg/kg for the tail-immersion, tail-pinch, and acetic acid writhing tests, respectively),

Formal name: 6-ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepin-2-amine, dihydrochloride

Synonyms:  Azepexole|Oxazoloazepin

Molecular weight: 254.2

CAS: 36067-72-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Behavioral Neuroscience||Research Area|Neuroscience|Pain Research

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