An atypical antipsychotic; binds to dopamine D1

Olanzapine – 100 mg

Brand:
Cayman
CAS:
132539-06-1
Storage:
-20
UN-No:
Non-Hazardous - /

Olanzapine is an atypical antipsychotic that binds to dopamine D1, D2, and D4 receptors (Kis = 31, 11, and 27 nM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2C, and 5-HT3 (Kis = 4, 11, and 57 nM, respectively).{21347} It also binds to M1 muscarinic acetylcholine, α1-adrenergic, and histamine H1 receptors (Kis = 2, 19, and 7 nM, respectively). Olanzapine (0.5 mg/kg, i.p.) decreases immobility time in the forced swim test in non-stressed and prenatally-stressed rats, indicating antidepressant-like activity.{42431} It also decreases the number of avoidances made in the conditioned avoidance response test in rats when administered at doses of 0.5 and 1 mg/kg.{42432} Formulations containing olanzapine have been used in the treatment of schizophrenia and bipolar disorder.  

 

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Description

An atypical antipsychotic; binds to dopamine D1, D2, and D4 receptors (Kis = 31, 11, and 27 nM, respectively) as well as 5-HT2A, 5-HT2C, and 5-HT3 receptors (Kis = 4, 11, and 57 nM, respectively); binds to M1 muscarinic acetylcholine, α1-adrenergic, and histamine H1 receptors (Kis = 2, 19, and 7 nM, respectively); decreases immobility time in the forced swim test in non-stressed and prenatally-stressed rats at 0.5 mg/kg; decreases the number of avoidances made in the conditioned avoidance response test in rats at 0.5 and 1 mg/kg ,

Formal name: 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine

Synonyms:  LY170053

Molecular weight: 312.4

CAS: 132539-06-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Neuroscience|Behavioral Neuroscience|Bipolar Disorder||Research Area|Neuroscience|Behavioral Neuroscience|Depression||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis

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