A 5-HT2B receptor antagonist (Ki = 0.5 nM); selective for 5-HT2B over 5-HT2A and 5-HT2C receptors (Kis = 19.5 and 24.55 nM

LY266097 (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
172895-39-5
Storage:
-20
UN-No:
Non-Hazardous - /

LY266097 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT2B (Ki = 0.5 nM).{49230} It is selective for 5-HT2B over 5-HT2A and 5-HT2C receptors (Kis = 19.5 and 24.55 nM, respectively).{49231} LY266097 (100 nmol, intrathecal) reduces hind paw tactile allodynia induced by L5/L6 spinal nerve ligation in a rat model of neuropathic pain.{49232} It also reduces hyperlocomotion induced by cocaine in rats when administered at a dose of 0.63 mg/kg without reducing cocaine-induced dopamine outflow in the nucleus accumbens shell.{36202}  

 

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Description

A 5-HT2B receptor antagonist (Ki = 0.5 nM); selective for 5-HT2B over 5-HT2A and 5-HT2C receptors (Kis = 19.5 and 24.55 nM, respectively); reduces L5/L6 spinal nerve ligation-induced hind paw tactile allodynia in a rat model of neuropathic pain at an intrathecal dose of 100 nmol; reduces hyperlocomotion induced by cocaine in rats at 0.63 mg/kg

Formal name: 1-[(2-chloro-3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole, monohydrochloride

Synonyms: 

Molecular weight: 407.3

CAS: 172895-39-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research||Research Area|Neuroscience|Pain Research

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