A synthetic oleanane triterpenoid that blocks iNOS and COX-2 synthesis in INF-γ-activated mouse macrophages (IC50 = 0.11 nM); induces apoptosis

CDDO methyl ester – 50 mg

Brand:
Cayman
CAS:
218600-53-4
Storage:
-20
UN-No:
Non-Hazardous - /

The synthetic oleanane triterpenoid CDDO (Item No. 81035) is a Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. The C-28 methyl ester of CDDO (CDDO methyl ester) blocks the cellular synthesis of inducible nitric oxide synthase (iNOS) and inducible COX-2 in INF-γ-activated mouse macrophages with an IC50 value of 0.11 nM.{9897,20969} It induces apoptosis, induces differentiation, and inhibits the inflammatory response in various tumor cells through inhibition of IκBα kinase/NF-κB signaling.{21755,21758} CDDO methyl ester has potent antidiabetic activity, reducing proinflammatory cytokine expression in high fat diet-fed type 2 diabetic mice and in Leprdb/db mice and triggering AMP-activated protein kinase and LKB1 activation in muscle and liver.{21757}  

 

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SKU: 11883 - 50 mg Category:

Description

A synthetic oleanane triterpenoid that blocks iNOS and COX-2 synthesis in INF-γ-activated mouse macrophages (IC50 = 0.11 nM); induces apoptosis, induces differentiation, and inhibits the inflammatory response in various tumor cells and has potent antidiabetic activity

Formal name: 2-cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid, methyl ester

Synonyms:  Bardoxolone methyl|NSC 713200|RTA 402|TP-155

Molecular weight: 505.7

CAS: 218600-53-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Innate Immunity

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