A potent activator of Nrf2-regulated activity

2-Trifluoromethyl-2′-methoxychalcone – 10 mg

Brand:
Cayman
CAS:
1309371-03-6
Storage:
-20
UN-No:
De Minimis - 1231 / 3

Nrf2 activation is central to cytoprotective gene expression against oxidative and/or electrophilic stress.{17702} Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1.{16386} Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents.{20661} 2-Trifluoromethyl-2′-methoxychalcone is a potent activator of Nrf2, both in vitro and in mice.{21374} Human bronchial epithelial cells treated with 10 μM 2-trifluoromethyl-2′-methoxychalcone showed a marked increase in the expression of the Nrf2-regulated antioxidant genes, GCLM and NQO1. Furthermore, treatment of mice mice with 50 mg/kg 2-trifluoromethyl-2’-methoxychalcone leads to a 4.5- and 4.6-fold increase in the expression of GCLM and NQO1, respectively, in the small intestine compared to controls.{21374}  

 

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SKU: 11881 - 10 mg Category:

Description

A potent activator of Nrf2-regulated activity, both in vitro (10 μM) and in mice (50 mg/kg)

Formal name: 1-(2-methoxyphenyl)-3-[2-(trifluoromethyl)phenyl]-2E-propen-1-one

Synonyms: 

Molecular weight: 306.3

CAS: 1309371-03-6

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Small Molecule Activators|Transcription Factors & Coactivators||Research Area|Cancer||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity

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