A steroidal saponin with diverse biological activities; reduces cell growth in a panel of 58 leukemia

Gracillin – 5 mg

Brand:
Cayman
CAS:
19083-00-2
Storage:
-20
UN-No:
Non-Hazardous - /

Gracillin is a steroidal saponin that has been found in C. speciosus and has diverse biological activities.{43305,43306,43307} It reduces cell growth in a panel of 58 leukemia, non-small cell lung, colon, CNS, prostate, melanoma, ovarian, renal, and breast cancer cell lines (GI50s = 0.58-2.44 μM).{43305} Gracillin reduces growth of fish Ich parasite (I. multifiliis) theronts (EC50 = 0.53 mg/L) and induces 100 and 92.5% mortality of I. multifiliis protomonts and encysted tomonts, respectively, when used at a concentration of 0.8 mg/L.{43306} It decreases the number of I. multifiliis-infected goldfish by approximately 75% when used at a concentration of 1 mg/L in tank water. Gracillin (100 mg/kg) reduces ear edema induced by arachidonic acid (Item No. 90010) in mice.{43307}  

 

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SKU: 11848 - 5 mg Category:

Description

A steroidal saponin with diverse biological activities; reduces cell growth in a panel of 58 leukemia, non-small cell lung, colon, CNS, prostate, melanoma, ovarian, renal, and breast cancer cell lines (GI50s = 0.58-2.44 μM); reduces growth of fish Ich parasite (I. multifiliis) theronts (EC50 = 0.53 mg/L) and induces 100 and 92.5% mortality of I. multifiliis protomonts and encysted tomonts, respectively, at 0.8 mg/L; decreases the number of I. multifiliis-infected goldfish by ~75% at 1 mg/L in tank water; reduces arachidonic acid-induced ear edema in mice at 100 mg/kg

Formal name: (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→3)]-β-D-glucopyranoside

Synonyms:  NSC 698787

Molecular weight: 885.1

CAS: 19083-00-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Saponins||Research Area|Cancer||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases

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