A major metabolite of glycyrrhizin

18β-Glycyrrhetinic Acid – 1 g

Brand:
Cayman
CAS:
471-53-4
Storage:
-20
UN-No:
Non-Hazardous - /

18β-Glycyrrhetinic acid is a major metabolite of glycyrrhizin (Item No. 11847), one of the main constituents of licorice. Both 18β-glycyrrhetinic acid and glycyrrhizin have been shown to exhibit anti-ulcerative, anti-inflammatory, and immunomodulatory properties. 18β-Glycyrrhetinic acid is an inhibitor of the complement pathway (IC50 = 35 μM).{21413} At 100 mg/kg/day, 18β-glycyrrhetinic acid is protective against diabetes complications by reducing lipid peroxidation and increasing antioxidant activity in diabetic rats.{21415} 18β-Glycyrrhetinic acid inhibits mammalian DNA polymerases α, γ, κ, and λ with IC50 values of 16.1, 19.3, 15.8, and 13.7 μM, respectively.{21414} At 100-200 μM, 18β-glycyrrhetinic acid suppresses LPS-induced TNF-α production and NF-κB activation in mouse macrophages.{21414}  

 

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SKU: 11845 - 1 g Category:

Description

A major metabolite of glycyrrhizin, a constituent of licorice that exhibits anti-ulcerative, anti-inflammatory, and immunomodulatory properties; at 100 mg/kg/day, reduces lipid peroxidation and increases antioxidant activity in diabetic rats; suppresses LPS-induced TNF-α production and NF-κB activation in mouse macrophages 100-200 μM

Formal name: (20β)-3β-hydroxy-11-oxo-olean-12-en-29-oic acid

Synonyms:  Arthrodont|Biosone|Enoxolone|GM 1658|NSC 35347|PO 12|STX 352|α-Glycyrrhetinic Acid​

Molecular weight: 470.7

CAS: 471-53-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Metabolic Syndrome||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Gastric Disease|Peptic Ulcers||Research Area|Immunology & Inflammation|Innate Immunity

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