A triterpenoid saponin; inhibits P-gp

Bacoside A3 – 5 mg

Brand:
Cayman
CAS:
157408-08-7
Storage:
-20
UN-No:
Non-Hazardous - /

Bacoside A3 is a triterpenoid saponin first isolated from B. monniera.{39061} Bacoside A3 inhibits the ATP-binding cassette transporter P-glycoprotein (P-gp), decreasing efflux 4-fold compared with control in vitro.{39064} An extract containing bacoside A3 and bacopaside II (4 and 1.3 µg/mg extract, respectively) administered for eight days at a dose of 10-30 mg/kg reduces opioid withdrawal-induced depression in mice using the forced swim test.{39062} Bacoside A3 also has antioxidant properties following liver and kidney damage induced by street heroin in rats.{39063}  

 

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SKU: 11824 - 5 mg Category:

Description

A triterpenoid saponin; inhibits P-gp, decreasing efflux 4-fold compared with control in vitro; a 3:1 extract of bacoside A3 to bacopaside II at 10-30 mg/kg for eight days reduces opioid withdrawal-induced depression in rats; has antioxidant properties

Formal name: (3β,16β,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-α-L-arabinofuranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→3)]-β-D-glucopyranoside

Synonyms:  Bacopa Pgp

Molecular weight: 929.1

CAS: 157408-08-7

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Saponins||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research||Research Area|Neuroscience|Behavioral Neuroscience|Depression||Research Area|Toxicology|Drug Metabolism

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