A triterpenoid saponin with diverse biological activities; inhibits the ATPase activity of P-glycoprotein (IC50 = 57.83 µg/ml); inhibits scopolamine-induced impairments in spatial memory in the Morris water maze and memory retrieval in the step-down test in mice at 50 mg/kg; has antidepressant-like activity in mice; reduces the spleen parasite load in a hamster model of leishmaniasis

Bacopasaponin C – 5 mg

Brand:
Cayman
CAS:
178064-13-6
Storage:
-20
UN-No:
Non-Hazardous - /

Bacopasaponin C is a triterpenoid saponin originally isolated from B. monniera that has diverse biological activities.{48521,48522,48523} It inhibits the ATPase activity of P-glycoprotein (IC50 = 57.83 µg/ml).{39064} Bacopasaponin C inhibits scopolamine-induced impairments in spatial memory in the Morris water maze and memory retrieval in the step-down test in mice when administered at a dose of 50 mg/kg.{48521} It also decreases the time mice spent immobile in the forced swim and tail suspension tests, indicating antidepressant-like activity.{48522} Bacopasaponin C reduces the spleen parasite load in a hamster model of leishmaniasis when administered as a free compound or in liposomal, niosomal, microencapsulated, or nanocapsulated forms.{48523}  

 

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Description

A triterpenoid saponin with diverse biological activities; inhibits the ATPase activity of P-glycoprotein (IC50 = 57.83 µg/ml); inhibits scopolamine-induced impairments in spatial memory in the Morris water maze and memory retrieval in the step-down test in mice at 50 mg/kg; has antidepressant-like activity in mice; reduces the spleen parasite load in a hamster model of leishmaniasis

Formal name: (1S,2R,4aR,6aS,6bR,8aR,10S,12aR,12bR,14aR,14bS)-hexadecahydro-1-hydroxy-1,6b,9,9,12a-pentamethyl-2-(2-methyl-1-propen-1-yl)-4a,6a-methano-1H,6H-phenanthro[2,1-d]pyrano[2,3-b]pyran-10-yl O-α-L-arabinofuranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→3)]-α-L-arabinopyranoside

Synonyms:  (–)-Bacopasaponin C

Molecular weight: 899.1

CAS: 178064-13-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Natural Products|Saponins||Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Leishmaniasis||Research Area|Neuroscience|Behavioral Neuroscience|Depression||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory

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